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Nader Ouaili

 

Nader Ouaili

The First Sechenov Moscow State Medical University, Russian Federation

Abstract Title:

Efficacy of low-temperature argon plasma in the treatment of non-segmental vitiligo

Research Interests:

Background: Vitiligo is a chronic depigmenting skin disease that significantly impacts the psychosocial well-being of patients. Current treatment methods, including long-term topical corticosteroids and laser technologies, have several limitations related to side effects and skin phototype dependence. This necessitates the development and implementation of new, safe, and effective treatments for vitiligo.

Materials and Methods: This prospective study included patients with non-segmental vitiligo (n=20). Low-temperature argon plasma treatments were performed three times weekly for 8 weeks, with a subsequent month of follow-up. Treatment efficacy was assessed using the Vitiligo Extent and Treatment Fraction (VETF) index, and quality of life was assessed using the Dermatological Quality of Life Index (DQLI). Standardized photographic documentation was used to assess the dynamics of repigmentation, the area of depigmented lesions.

Results: Upon completion of therapy, all patients demonstrated positive dynamics with varying degrees of repigmentation. A statistically significant decrease in VETF scores from 8.4±3.6 to 3.6±2.4 points (p<0.001) and a decrease in DQLI from 18.6±5.4 to 7.4±2.9 points (p<0.001) were observed, indicating an improvement in the patients' quality of life. The area of depigmentation decreased from 4.6±2.8% to 2.0±1.8% of the body surface area (p<0.001). The best results were achieved in patients with a disease duration of less than three years and in lesions located on the face, neck, and trunk. Follicular repigmentation was the predominant type (in 16 patients).

Conclusion: Therapy with the Plazmoran plasma arc installation demonstrated high clinical efficacy and a favorable safety profile in the treatment of non-segmental vitiligo. The method did not cause serious adverse events typical of traditional treatments and was independent of skin phototype.